Генетические маркеры успешности спортивной деятельности единоборцев

С. Б. Мельнов, А. С. Козлова, Т. Л. Лебедь, Н. Г. Кручинский

Анотація


Виявлено специфічні особливості генотипу, що є характерними для спортсменів, котрі спеціалізуються у різних видах єдиноборств. Проаналізовано поширеність поліморфізмів за генами ACE, AGT, AT2R1, ADRB2, 5HTT, 5HT2A, COMT, GSTM1, GSTT1, TFAM, PPARA, PPARGC1A и ACTN3. Показано значущі відмінності між основною групою і групою порівняння за частотою зустрічальності алелів генів ACE, AT2R1, 5HT2A, GSTM1, GSTT1, TFAM, PPARA, PPARGC1 и ACTN3.


Ключові слова


спортивна генетика; гени-маркери; однонуклеотидний поліморфізм; єдиноборства

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Посилання


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Пристатейна бібліографія ГОСТ


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Charbonneau D. E. ACE genotype and the muscle hypertrophic and strength responses to strength training / D. E. Charbonneau, E. D. Hanson, A. T. Ludlow // Med. and Sci. in Sports and Exercise. – 2008. – Vol. 40 (4). – P. 677–683.

Chee I. S. 5-HT2A receptor gene promoter polymorphism -1438A/G and bipolar disorder / I. S. Chee, S. W. Lee, J. L. Kim et al. // Psychiatr. Genet. – 2001. – Vol. 11 (3). – P. 111–114.

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Costa A. M. Association between ACE D allele and elite short distance swimming / A. M. Costa, A. J. Silva, N. D. Garrido // Eur. J. Appl. Physiol. – 2009. – Vol. 106. – P. 785–790.

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Flavell D. M. Peroxisome proliferator-activated receptor α gene variation influences age of onset and progression of type 2 diabetes / D. M. Flavell, H. Ireland, J. W. Stephens et al. // Diabetes. – 2005. – Vol. 54. – P. 582–586.

Hung R. J. CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis / R. J. Hung, P. Boffetta, J. Brockmöller et al. // Carcinogenesis. – 2003. – Vol. 24(5). – P. 875–882.

Johanson H. DNA elution from buccal cells stored on Whatman FTA Classic Cards using a modified methanol fixation method / H. Johanson, V. Hyland, C. Wicking et al. // Botechniques. – 2009. – Vol. 46(4). – P. 309–311.

Joseph A. M. Control of gene expression and mitochondrial biogenesis in the muscular adaptation to endurance exercise / A. M. Joseph, H. Pilegaard, A. Litvintsev et al.// Essays Biochem. – 2006. – Vol. 42. – P.13–29.

Karjalainen J. Angiotensinogen gene M235T polymorphism predicts left ventricular hypertrophy in endurance athletes / J. Karjalainen, U. M. Kujala, Stolt A. // J. Am Coll Cardiol. – 1999. – Vol. 34. – P. 494–499.

Lippi G. The genetic basis of human athleticperformance. Why are psychological components so often overlooked? / G. Lippi, E. J. Favaloro, G. C. Guidi // J. Phy­ siol. – 2008. – Vol. 12. – P. 586.

Masetti S. Interactive effect of the glutathione S-trans­ ferase genes and cigarette smoking on occurrence and severi­ ty of coronary artery risk / S. Masetti, N. Botto, S. Manfredi et al. // J. Mol Med. – 2003. – Vol. 81(8). – P. 488–494.

Masud R. Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease. / R. Masud, I. Z. Qureshi // Mol Cell Biochem. – 2011. – Vol. 355(1–2). – P. 289–297.

Moran C. N. Association analysis of the ACTN3 R577X polymorphism and complex quantitative body composition and performance phenotypes in adolescent Greeks / C. N. Moran, N. Yang, M. E. Bailey // Eur. J. Hum. Genet. – 2007. – Vol.15(1). – P. 88–93.

Niemi A. K. Mitochondrial DNA and ACTN3 genotypes in Finnish elite endurance and sprint athletes / A. K. Niemi, K. Majamaa // Eur. J. Hum. Genet. – 2005. – Vol. 13(8). – P. 965–969.

Papadimitriou I. D. The ACTN3 gene in elite Greek track and field athletes // I. D. Papadimitriou, C. Papadopoulos, A. Kouvatsi et al. / Int J. Sports Med. – 2008. – Vol. 29(4). – P. 352–355.

Rankinen T. The human gene map for performance and health-related fitness phenotypes: the 2005 update / T. Rankinen, M. S. Bray, J. M. Hagberg et al. // Med Sci Sports Exerc. – 2006. – Vol. 38(11). – P. 1863–1888.

Roth S. M. The ACTN3 R577X nonsense allele is under-represented in elite-level strength athletes / S. M. Roth, S. Walsh, D. Liu et al. // Eur. J. Hum. Genet. – 2008. – Vol. 16(3). – P. 391–394.

Seto J. T. ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling. / J. T. Seto, K. G. Quinlan, M. Lek et al. // J. Clin Invest. – 2013. – Vol. 123. – P. 4255–4263.

Squire et al. Fundamental neuroscience (3rd ed. ed.). Amsterdam: Elsevier. Academic Press, 2009. – P. 143.

Stefan N. Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention / N. Stefan, C. Thamer, H. Staiger et al. // J. Clin. Endocr. Metab. – 2007. – Vol. 92. – P. 1827–1833.

Stroth S. Impact of aerobic exercise training on cognitive functions and affect associated to the COMT polymorphism in young adults / S. Stroth, R. K. Reinhardt, J. Thöne et al. // Neurobiol Learn Mem. – 2010. – Vol. 94(3). – P. 364–372.

Vimaleswaran K. S. The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a metaanalysis involving 13,949 individuals / K. S. Vimaleswaran, J. Luan, G. Andersen et al. // J. Appl. Physiol. – 2008. – Vol. 105(4). – P. 1352–1358.

Wahlstrom D. Variations in the catechol O-methyltransferase polymorphism and prefrontally guided behaviors in adolescents / D. Wahlstrom, T. White, C. J. Hooper et al. // Biol Psychiatry. – 2007. – Vol. 61(5). – P. 626–632.

Wang Z. The relationship between combat-related posttraumatic stress disorder and the 5-HTTLPR/rs25531 polymorphism / Z. Wang, D. G. Baker, J. Harrer et al. // Depress Anxiety. – 2011. – Vol. 28(12). – P. 1067–1073.

Wisloff U. Cardiovascular risk factors emerge after artificial selection for low aerobic capacity / U. Wisloff, S. M. Najjar, O. Ellingsen et al. // Sci. – 2005. – Vol. 307.– P. 418–420.

Wolfarth B. Association between a beta2-adrenergic receptor polymorphism and elite endurance performance / B. Wolfarth, T. Rankinen, J. Scherr et al. // Metabolism. – 2007. – Vol. 56(12). – P. 1649–1651.

Wu Z. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 / Z. Wu, P. Puigserver, U. Andersson et al. // Cell. 1999. – Vol. 98. – P. 115–124.

Yang N. ACTN3 genotype is associated with human elite athletic performance / N. Yang, D. G. MacArthur, J. P. Gulbin et al. // Am. J. Hum. Genet. – 2003. – Vol. 73(3). – P. 627–631.



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