Молекулярно-генетические маркеры спортивного травматизма

С. Б. Дроздовская, В. Н. Ильин

Анотація


З’ясовано можливості використання молекулярно-генетичного аналізу з метою визначення ризику виникнення спортивного травматизму. Встановлено гени, поліморфізми яких асоційовані зі змінами морфофункціонального стану опорно-рухового апарату і, опосередковано, можуть бути факторами, що сприяють підвищенню ризику виникнення спортивних травм у спортсменів. До генів-кандидатів віднесено гени колагенів; гени матриксних і дизінтегрінподібних металопротеїназ та їхніх інгібіторів; гени протеогліканів; гени місцевих регуляторів (цитокіни); гени ангіогенезу.


Ключові слова


поліморфізми генів; спортивний травматизм; молекулярно-генетичні маркери; ризик виникнення травми

Повний текст:

PDF (Русский)

Посилання


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Пристатейна бібліографія ГОСТ


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Grainger D. J. Genetic control of the circulating concentration of transforming growth factor type beta L / D. J. Grainger, K. Heaathcote, M. Chiano [et al.] // Hum. Mol. Genet. – 1999. – N 8. – P. 93–97.

Gwilym S. E. Genetic influences in the progression of tears of the rotator cuff/ S. E. Gwilym, B. Watkins, C. D. Cooper [et al.] // J. Bone and Joint Surg. Br. – 2009. – Vol. 91, N 7. – P. 915–917.

Harvie P. Genetic influences in the aetiology of tears of the rotator cuff: sibling risk of a fullthickness tear / P. Harvie, S. J. Ostlere, J. Teh [et al.] // J. Bone and Joint Surg. Br. – 2004. – Vol. 86, N 5. – P. 696–700.

Hootman J. M. Epidemiology of Collegiate Injuries for 15 Sports: Summary and Recommendations for Injury Prevention Initiatives/ J. M. Hootman, R. Dick, J. Agel // J. Athl. Train. – 2007. – Vol. 42, N 2. – P. 311–319.

Jones G. C. Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achules tendon/ G. C. Jones., A. N. Corps, C. J. Pennington [et al.] // Arthritis Rheum. – 2006. – Vol. 54, N 3. – P. 832–842.

MacDonald H. N. COLIAI Spl polymorphism predicts perimenopausal and early postmenopausal spinal bone loss/ H. N. MacDonald, F. A. McGuigan, S. A. New [et al.] // J. Bone Miner. Res. – 2001. – Vol. 16, N 9. – P. 1634.

Mokone G. G. The C0L5A1 gene and Achilles tendon pathology / G. G. Mokone, M. P. Schwellnus, T. D. Noakes [et al.] // Scand. J. Med. Sei Sports. – 2006. – Vol. 16, N 1. – P. 19–26.

Mokone G. G. The guaninethymine dinucleotide repeat polymorphism within the tenascin-C gene is assoeiated with achules tendon injuries / G. G. Mokone, M. Gajjar, A. V. September [et al.] // Amer. J. Sports Med. – 2005. – Vol. 33, N 7). – P. 1016–1021.

Kannus P. Etiology and pathophysiology of tendon ruptures in sports/ P. Kannus, A. Natri // Scand. J. Med. Sei Sports. – 1997. – Vol. 7, N 2. – P. 107–1012.

Karousou E. Collagens, proteoglycans, MMP-2, MMP-9 and TIMPs in human achules tendon rupture / E. Karousou, M. Ronga, D. Vigetti [et al.] // Clin. Orthop Relat Res. – 2008. – Vol. 466, N 7. – P. 1577–1582.

Keen R. W. Evidence of association and linkage disequilibria between a novel polymorphism in the transforming growth factor-beta 1 gene and hip bone mineral density: a study of female twins/ R. W. Keen, H. Snieder, H. Molloy [et at.] // Rheumatology (Oxford). – 2001. – Vol. 40. – P. 48–54.

Knobloch K. Acute and overuse injuries correlated to hours of training in master running athletes/ K. Knobloch, U. Yoon, P. M. Vogt // Foot Ankle Int. – 2008. – Vol. 29, N 7. – P. 671–676.

Khoury L. El. Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 AND TIMP2 genes and the risk of achilles tendon pathology; a genetic association study / L. El. Khoury, M. Posthumus, M. Collins et al.] // J. Sci. and Medicine in Sport – 2013. – N 16. – P. 493–498.

Lopes A. D. What are the Main Running-Related Musculoskeletal Injuries? / A. D. Lopes, L. C. Hespanhol Junior, S. S. Yeung, L. O. Pena Costa // Sports Med. – 2012. – Vol. 42, N 10. – P. 891–905.

Lysholm J. Injuries in runners /Lysholm J, Wiklander J. // Amer. J Sports Med. – 1987. – Vol. 15, N 2. – P. 168–171.

Mannion S. Genes encoding proteoglycans are associated with the risk of anterior cruciate ligament ruptures / S. Mannion, A. Mtintsilana, W. van der Merwe [et al.] // Book of Abstracts of the 18th Annual Congress of the European College of Sport Science: Barcelona, 2013. – P. 376.

Paoni N. F. Time course of skeletal muscle repair and gene expression following acute hind limb ischemia in mice/ N. F. Paoni, F. Peale, F. Wang [et al.] // Physiol. Genomics. – 2002. – N 11. – P. 263–272.

Petersen W. Expression of VEGFR-1 and VEGFR-2 in degenerative Achilles tendons / W. Petersen, T. Pufe, T. Zantop [et al.] // Clin. Orthop. Relat Res. – 2004. – Vol. 420. – P. 286–291.

Posthumus M. Investigation of the Spl-binding site polymorphism within the COLlAl gene in participants with Achilles tendon injuries and controls / M. Posthumus, A. V. September, M. P. Schwellnus [et al.] // J. Sei Med. Sport. – 2009. – Vol. 12, N 1. – P. 184–189.

Posthumus M. Components of the transforming growth factor-beta family and the pathogenesis of human Achilles tendon pathology: a genetic association study/ M. Posthumus // Rheumatology. – 2010. – Vol. 49. – P. 2090–2097.

Posthumus M. The Col12A1 gene is associated with increased risk of anterior cruciate ligament ruptures in Females / M. Posthumus, A. September, D. O`Cuinneagainet [et al.] // Book of Abstracts of the 14th Annual Congress of the European College of Sport Science: Oslo, 2009. – P. 266.

Puthucheary Z. Genetic Influences in Sport and Physical Performance / Z. Puthucheary, J. R. A. Skipworth, J. Ra­ wal [et al.] // Sports medicine. – 2011. – Vol. 41, N 10. – P. 845–859.

Rahim M. The association of genes involved in the angiogenesis-associated cell signalling pathway with risk of anterior cruciate ligament rupture/ M. Rahim, A. Gibbon, H. Hobbs [et al.] // Book of Abstracts of the 18th Annual Congress of the European College of Sport Science: Barcelona, 2013. – P. 53.

Ribbans W. J. Pathology of the tendo Achills / W. J. Ribbans, M. Collins//Bone Joint J. – 2013. – Vol. 95. – P. 305–313.

Saracini C. Polymorphisms of genes involved in extracellular matrix remodeling and abdominal aortic aneurysm / C. Saracini, P. Bolli, E. Sticchi [et al.] // J. vascular surgery. – 2012. – Vol. 55, N 1. – P. 171–179.

September A. V. Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations / A. September, J. Cook, C. J Handley [et al.] // Br. J. Sports Med. – 2009. – Vol. 43. – P. 357–365.

September A. V. Investigation of genes involved in the cell-signalling pathway with risk of anterior cruciate ligament rupture / A. V. September, M. Rahim, S. Mannion [et al.] // Book of Abstracts of the 18th Annual Congress of the European College of Sport Science: Barcelona, 2013. – P. 72.

Taboulet J. Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women / J. Taboulet, M. Frenkian, J. L. Frendo [et al.] // Hum. Mol. Genet. – 1998. – Vol. 7, N 13. – P. 2129.

Vogel K. G. What happens when tendons bend and twist? Proteoglycans. / K. G. Vogel // J. Musculoskelet Neuronal Interact. – 2004. – Vol. 4, N 2. – P. 202–203.

Waggett A. D. Characterization of collagens and proteoglycans at the insertion of the human Achilles tendon/ A. D. Waggett, J . R. Ralphs, A. P. Kwan [et al.] // Matrix Biol. – 1998. – Vol. 16, N 8. – P. 457–470.

Zmuda J. M. Vitamin D receptor gene polymorphisms, bone turnover, and fates of bone loss in older African-American women/ J. M. Zmuda, A. Cauley, E. M. Danielson [et al.] // J. Bone Miner. Res. – 1997. – Vol. 12, N 9. – P. 1446. 15.5



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